TGF-1 is an important cytokine that induces fibrosis in organs such as the kidneys and lungs [39, 40], and can activate PSCs to induce pancreatic fibrosis [41, 42]
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*Correspondence: Cesare Indiveri, [email protected] This article was submitted to Mitochondrial Research, a section of the journal Frontiers in Physiology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers
This SC layer forms the principal barrier to drug permeation, largely due to its unique lipid composition, predominantly ceramides, cholesterol, fatty acids, and cholesteryl sulfate, arranged in bilayer structures within intercellular spaces [48, 223,224,225]
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