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TZDs are known to improve insulin sensitivity and preserve -cell function, and several mechanisms have been proposed (Fig

14.3 Combination Therapy Use of OZEMPIC in Patients with Type 2 Diabetes Mellitus Combination with metformin and/or thiazolidinediones In a 56-week, double-blind trial (NCT01930188), 1231 patients with type 2 diabetes mellitus were randomized to OZEMPIC 0.5 mg once weekly, OZEMPIC 1 mg once weekly, or sitagliptin 100 mg once daily, all in combination with metformin (94%) and/or thiazolidinediones (6%)

The enzyme alliinase breaks down alliin and similar compounds to form dehydroalanine and allyl sulfenic acid

Some clinician-guided protocols extend the on-period to week 16