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Disruption at any pointsubstrate limitation, enzymatic insufficiency, impaired NADPH availability, or excessive oxidative burdendrives this ratio downward, shifting cells toward an oxidized redox state

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It does not cause physical dependence, withdrawal symptoms, or the heavy sedation associated with pharmaceutical anxiolytics like benzodiazepines

Conclusions It is clear that smoking impairs vascular endothelial function and leads to atherosclerosis