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Over a year, 87.8% of participants in the tirzepatide group lost 5% or more of their body weight, compared to 71.8% of those in the semaglutide group

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Constipation: Gases produced are dependent on the health of the gut microbiome

The absolute number depends on three factors: starting body composition, dose escalation speed, and the size of the calorie deficit the drug creates

Additionally, the gut microbiota of the MT group and FMT group were similarly disrupted after antibiotic treatment, with the microbial body transplantation recovering the gut microbiota faster than the supernatant transplantation (Figure 5C)