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[1] Carnitine shuttle system [edit] The free-floating fatty acids, released from adipose tissues to the blood, bind to carrier protein molecules known as serum albumin that carry the fatty acids to the cytoplasm of target cells such as the heart, skeletal muscle, and other tissue cells, where they are used for fuel

Mitochondrial damage causes ATP depletion and ROS burst, exacerbating inflammation and disrupting the intestinal barrier

L-carnitine is responsible for transporting medium- and long-chain fatty acids across mitochondrial membranes, promoting their oxidation and subsequent energy production

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Fatty acyl-CoA undergoes -oxidation within mitochondria to produce energy, and L-carnitine is transported to the cytoplasm again by CACT (As show in Figure 1)