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106 Following pioneering studies that linked CBS overexpression with colorectal and ovarian cancer (Table 1), an increase in the expression of all enzymes involvedindividually or jointlyin the synthesis of H 2 S has also been reported for breast, gastric, lung, liver, bladder, kidney and prostate carcinomas, melanoma, neuroblastoma, glioma and astrocytoma

Bahnson JL, Knowler WC, Bantle JP, Bertoni AG, Bray GA, Chen H et al (2014) Effect of a long-term behavioural weight loss intervention on nephropathy in overweight or obese adults with type 2 diabetes: a secondary analysis of the Look AHEAD randomised clinical trial

Key points Vascular damage in chronic kidney disease (CKD) increases the risk of stroke and cognitive impairment, with faster CKD progression linked to cerebral damage, subcortical infarcts and bloodbrain barrier disruption

Circular RNA HECTD1 mitigates ulcerative colitis by promoting enterocyte autophagy via miR-182-5p/HuR Axis

Although clinical sample sizes remain moderate, results consistently demonstrate enhanced redox stability and reduced inflammatory stress in treated tissues