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doi: 10.1016/S0014-2999(98)00818-8
Knowing which metric moved, and whether it rose above baseline or only fell more slowly, is what separates a lasting result from a temporary one, which is also why measuring brain aging across several markers at once gives a steadier read than any single number
While the anti-inflammatory properties of GLP-1 therapy are promising, clinicians should counsel patients that definitive evidence for direct joint pain relief independent of weight loss is lacking
Retatrutide could represent the next evolution in obesity treatment