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Compounds that demonstrate clear efficacy in rat tendon healing studies have repeatedly failed to reproduce those effects in human clinical trials this is a documented pattern across pharmaceutical development, not a theoretical concern

Body Composition & Metabolic Research The downstream metabolic effects of ipamorelin-stimulated GH/IGF-1 axis activation including GH-mediated lipolysis in adipose tissue, IGF-1-mediated skeletal muscle protein synthesis, and nitrogen retention have made ipamorelin a useful tool in preclinical body composition research

Davies H, Bignell GR, Cox C, Stephens P, Edkins S, Clegg S et al

(2023) 11(8 Pt 1):100010

Chronic Inflammation: Conditions that keep the immune system on "high alert" can deplete glutathione rapidly