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Reduced Quantal Size : Under repeated amphetamine exposure, the combination of vesicular NE displacement (via proton gradient collapse) and VMAT2 blockade prevents newly recycled or recruited vesicles from being effectively refilled with NE (Sulzer et al, 1995

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These compounds show promise as standalone therapies and in combination with established treatments, as harnessing their anti-inflammatory actions can be broad, yet targeted, suppressing multiple cytokines simultaneously (Table 1, Fig