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In the mechanism of DKD, in addition to Kelch-1ike ECH-associated protein l (Keap1)/Nrf2/antioxidant response element (ARE) signaling, Nrf2 can inhibit inflammation to relieve kidney damage by suppressing NF-B, Sirtuin1 (SIRT1) and nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3)[104, 126]

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J Gerontol Ser A Biol Med Sci 62(5):490499 Iizumi T, Takahashi S, Mashima K, Minami K, Izawa Y, Abe T, Hishiki T, Suematsu M, Kajimura M, Suzuki N (2016) A possible role of microglia-derived nitric oxide by lipopolysaccharide in activation of astroglial pentose-phosphate pathway via the Keap1/Nrf2 system

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Physiological reports

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In this particular, GA reduced Na + -independent Glu binding to synaptic plasma membranes (receptors) from cerebral cortex and striatum only in infant (aged 7 and 15 days), but not in adult rats (60 days old)

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