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J Biol Chem (1999) 274:114558

Mesenchymal Stem/Stromal cell-Targeted Therapies for Solid Tumors and Hematological Malignancies

AFQ1 toxicity was also shown to be about 1% of AFB1 in rainbow trout (Eaton and Gallagher, 1994) and 18-times less toxic than AFB1 in chicken embryo assay (Hsieh et al., 1974)

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Taken together, these findings suggest that APR-246 could induce tumor cell death through both reactivation of mutant p53 and inhibition of cellular thiol-dependent redox system proteins (GPX4, TXNDR1, GRX1), providing novel combinatorial strategies for AML therapy