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However, rapid or significant weight loss can sometimes lead to nutrient imbalances, including deficiencies in iron, B12, and folate

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doi: 10.1074/jbc.M112.442939 254 GilkesDMBajpaiSWongCCChaturvediPHubbiMEWirtzDet al

Regarding the vagal influence, signalling is interrupted in the intrapancreatic ganglia and transmitted, via nicotinic receptors, to secondary neurons innervating the islets