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The E-cadherinMerlinHippoYAP axis has been shown to control ACSL4 transcription, thereby linking cellcell contact signaling to ferroptosis susceptibility [93], and further supporting ACSL4 as a pivotal mediator of ferroptotic regulation [94]

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30 However, most studies show that the addition of laxatives is usually necessary and more effective than behavior modification alone

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Ethics declarations Competing interests The authors declare that they have no known competing financial interests or personal relationship that could have appeared to influence the work reported in this article