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Consequently, NRF2 SUMOylation plays a key role in promoting signaling pathways that support HCC tumorigenesis, both under normal conditions and in response to metabolic stress [131]

In pathological states such as PCOS, dyslipidemia amplifies these patterns, and luteal-phase improvements appear blunted [126]

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however, in pathological states such as neurodegenerative diseases, autoimmune disorders, and cancer, extensive metabolic reprogramming occurs, resulting in impaired glucose metabolism and mitochondrial dysfunction, which accelerate disease progression

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