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Dadas las diferencias en dieta, metabolismo y hbitos de salud entre poblaciones, los autores subrayan la necesidad de evaluar estos tratamientos en contextos ms diversos

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In PD, activation of Nrf2 exerts neuroprotective effects by counteracting neuroinflammation

27 Consistent with these findings, a large global retrospective cohort study involving over 5 million individuals with obesity across 17 countries supported the neuroprotective potential of semaglutide in people with obesity, revealing reduced rates of AD (relative risk [RR] of 0.627), Lewy body dementia (RR of 0.59), vascular dementia (RR of 0.438), and PD (RR of 0.574)