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Table 1 links recurrent TME phenotypes to dominant barriers, design objectives, candidate nanotherapeutic strategies and key translational cautions

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5 m-thick sections were stained with hematoxylin and eosin (H&E) or picrosirius red solution (Abcam #ab150681) following manufacturers protocol as previously described ( 2.8 Statistical analyses All the data are presented as mean SEM and analysed by unpaired two-tailed Students t-test or two-way ANOVA with Bonferroni or Tukeys post-hoc test as appropriate using GraphPad Prism

Afzal O, Altamimi ASA, Nadeem MS, Alzarea SI, Almalki WH, Tariq A et al (2022) Nanoparticles in drug delivery: From history to therapeutic applications

Int J Mol Sci 25(8):4463 Kahaly GJ (2020) Management of Graves thyroidal and extrathyroidal disease: an update