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It's a very potent signaling molecule because it's 10 million times more potent than brain derived neurotropic factor

Microbial sources, such as endophytic fungi associated with plants like Vitex payos , have also been identified as producers of phenolic compounds with strong antioxidant properties, attributed to their redox properties and free radical scavenging abilities (Sibanda et al., 2018)

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[16] reported that sensitization of mechano-responsive A- and C-fibers did not explain pain behavior 45 min after an incision in the rat hind paw