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The earlier SUSTAIN dose-finding studies for diabetes (Nauck et al., Diabetes Care, 2016) tested multiple dose levels including 0.05 mg, 0.1 mg, 0.2 mg, 0.3 mg, and 0.4 mg daily (note: daily, not weekly) of oral semaglutide and found dose-dependent reductions in HbA1c and body weight at every dose tested

Most side effects are mild and tend to improve as the body adjusts over several weeks

They also slow gastric emptying, prolonging the feeling of fullness after meals and reducing overall caloric consumption

In select situations, preoperative GLP-1-RA discontinuation may be considered, with the caveat that it may result in perioperative hyperglycemia