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Researchers observed that GHRP-6 binding activates Gq-coupled signaling, leading to phospholipase C activation, inositol trisphosphate (IP3) generation, and intracellular calcium mobilization in pituitary somatotrophs

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Moreover, LC administrated for 2 weeks suppresses atrogin-1 messenger RNA (mRNA) level in suspended rats hindlimb [35], and only 7 days of LC administration downregulates MuRF-1 and atrogin-1 mRNAs reducing muscle wasting in a rat model of cancer cachexia [32]