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Oxidative stress can occur as a result of increased metabolic rate, increased oxygen tension, compromise of normal cellular antioxidants and many others endogenous and exogenous factors (Figure 1)

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Consequently, GLP1R agonists might be double-edged swords activating anti-addictive results and inducing Suicide Ideation through empowering the depressive phenotypes

D) HEK-GLP-1R cells were stimulated with either isoproterenol (100 M), compound 2 (1 M) or the two in combination (Co-addition) in the presence of IBMX and 5% DMSO (vehicle)