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Studies that describe alterations in the functional connectivity of the cerebral networks, particularly within the networks that involve the amygdala and insular cortex, can better explain the role of brain anomalies in CVS.41 In a case-control study, patients with CVS showed increased functional integrity of salience intrinsic connectivity to the middle/posterior insula, a key region of the brain for nausea and viscerosensory processing.41 It is possible that this neuronal hyperexcitability and a lower threshold for triggering specific patterns within the CNS predispose to the triggering of stereotypic vomiting episodes in CVS

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The net effect in clinical trials was a significant improvement in glycemic parameters, including reductions in HbA1c, fasting glucose, and insulin levels

Avan, The therapeutic potential of PI3K/Akt/mTOR inhibitors in breast Cancer: rational and progress

Because tirzepatide can be potent, even route and dose strategy should be discussed carefully with a provider