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Both families of enzymes use NADP + as cofactors to perform reversible reactions, where isocitrate is oxidatively decarboxylated to alpha-ketoglutarate and generates one NADPH per reaction

Consequently, cellular iron homeostasis, polyunsaturated fatty acid (PUFA) metabolism and oxidation, and antioxidant systems play crucial roles in influencing ferroptosis, involving a cascade of protein regulatory mechanisms

20254088), Key Program of National Natural Science Foundation of China (No

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For dilution, dissolving, or reconstitution of medications as directed by a healthcare professional