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Reaction of uric acid with peroxynitrite and implications for the mechanism of neuroprotection by uric acid

10.1093/jaoacint/qsaa015 46 United Nations Department of Economic and Social Affairs (2021)

Pharmacological inhibition of MAOB in PTSD-like mice model (MAOB-inhibitor drug therapy) To evaluate whether pharmacological inhibition of MAOB could reverse PTSD-related symptoms, we utilized KDS2010 36 , a potent, selective, and reversible MAOB inhibitor

Meanwhile, autophagy could be activated by rapamycin via PI3K/mTOR signaling pathway, and thus, protects hippocampal neurons from degeneration by decreasing the levels of prooxidants (Kotagale et al., 2020)

FOXO4-DRI achieves high intracellular concentrations that remain stable for at least 72 hours following administration