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Data from all the studies show different polymorphisms of the CAT gene among different populations in various regions of the world

Oral mucosal melanin hyperpigmentation associated with syndromes and systemic diseases Oral mucosal melanin hyperpigmentation is often observed in the systemic conditions such as Peutz-Jegher syndrome, McCune-Albright syndrome, Laugier-Hunziker syndrome, Addison disease, and neurofibromatosis

It directly explains why you cannot convert one dose to the other and why the weight loss numbers differ so significantly