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Inhibitory effects of S-nitrosoglutathione on cell proliferation and DNA synthesis: possible role of glyoxalase I inactivation

In May 2025, Novo Nordisk submitted this new dose for FDA review

In native physiology, the six IGFBPs perform several overlapping regulatory jobs: they extend the circulating half-life of IGF-1, they create a reservoir of hormone that can be released as needed, they modulate the amount of free peptide available to receptors, and in some contexts they exert IGF-independent effects of their own

Z Psychol

This could increase side effects and even be dangerous without providing additional benefits