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Severe constipation with abdominal pain, vomiting, or inability to pass gas requires immediate medical attention as it may indicate bowel obstruction, a rare but serious complication

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People should also talk to their health care provider before any planned surgeries or procedures and be prepared to discuss their up-to-date medical history, including a current list of prescribed medications and treatments

Testosterone production peaks during deep sleep

A further subtype of goblet cells also exists, known as sentinel goblet cells (Birchenough et al