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For one, it makes a robust clinical trial logistically tricky, said Christopher Milne, past director of research at the Tufts Center for the Study of Drug Development

injections are chosen for rapid repletion or malabsorption

High-frequency irreversible electroporation brain tumor ablation: exploring the dynamics of cell death and recovery

Since CSF entry correlated with plasma concentration and plasma half-life, [4] a route that lowers the plasma peak should lower central exposure further still