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Anatomically, the olfactory epithelium localization in the nasal cavity roof leads to difficult drug access to the targeted region

Cen LP, Ng TK, Liang JJ, Xu C, Zhuang X, Liu YF et al

Our results showed that different members of the GhGPX gene family were co-ordinately regulated under specific environmental stress conditions, and suggested the importance of GhGPXs in hormone treatments and abiotic stress responses

Lower doses may not achieve the receptor activation required for meaningful clinical benefit

However, the knockout of SIRT2 contributes to the increased acetylation level of septin4-K174 and aggravates oxidative stress and kidney injury in Ang II-induced HTN mice (Dikalov and Kirabo, 2023