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The pharmacological rationale is supported by GLP-1 receptor dose-response data and semaglutide's pharmacokinetic profile (Kapitza et al., J Clin Pharmacol, 2015), though no dedicated randomized controlled trial has validated a specific microdose protocol

Most clinicians recommend starting the new medication at its lowest dose and escalating even if you were on a high dose of the previous medication, because receptor sensitivity and side effect profiles differ

But they both have meaningful shortcomings that matter if you care about what actually ends up in your research protocol

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