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The kidney is the primary excretory organ for platinum-based agents and their metabolites, with the vast majority of the agents ultimately excreted via urine
This cycle plays a key role in maintaining the intracellular reducing environment, protecting protein sulfhydryl groups, and regulating oxidative signaling by rapidly responding to changes in reactive oxygen species (ROS) levels
In contrast, a workflow built around a preserved repeated-entry vial will read the bac water label first
Free Radical Biol Med (2022) 178:34759
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