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STEP UP: In adults with obesity, along with diet and exercise, Wegovy HD (semaglutide) injection 7.2 mg: Designed to deliver greater weight-loss results than the Wegovy you know 1 Mean change in body weight (%) from week 0 to week 72 1 Co-primary end point 1 : Percentage of patients achieving 5% weight loss at 72 weeks: 88.7% of patients with Wegovy vs 38.3% with placebo HD Treatment regimen estimand: This estimand is based on the intention-to-treat principle and was used as the primary analysis method *Co-primary end point: % change in body weight for Wegovy HD vs placebo

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18 Currently, efficacy and the safety of two doses (800 mg and 1,200 mg) of lanifibranor per day for 24 weeks is being evaluated in a phase II study versus placebo in adult NASH patients with moderate to severe necroinflammation without cirrhosis (NCT03008070)