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Being the proximal tubule a major target for many nephrotoxicants, it is logical that cell-based in vitro models that seek to resemble this segment of the nephron should be characterized by the expression of important markers, including SLC22A6 (OAT1), SLC22A8 (OAT3), SLC22A2 (OCT2) on the basolateral membrane and ABCB1 (P-gp), SLC47A1 (MATE1), SLC47A2 (MATE2), ABCC2 (MRP2), ABCC4 (MRP4), ABCG2 (BCRP), and the endocytosis receptors megalin and cubilin on the apical membrane (Bajaj et al
Are polyphenols effective when placed on the skin in a bag of green tea leaves steeped in water
10.1016/j.clinthera.2019.12.012 13 DoumasM.Imprialos.StavropoulosK.ReklouA.SachinidisA.AthyrosV
However, excess usage may cause gastrointestinal discomfort, fishy body odor (in sweat, breath, or urine), allergic reactions, stomach upset, diarrhea, and heartburn
