Surgery induced immunosuppression
Folate, particularly methylfolate, can worsen this by further increasing SERT and dopamine transporter (DERT) activity, potentially leading to increased anxiety, OCD-like symptoms, emotional instability, and cognitive rigidity
Discussing your genetic predispositions and baseline metabolic markers with your provider before starting GLP-1 therapy can support more personalized dosing adjustments, timeline expectations, and identification of any confounding health factors that may slow or accelerate your individual response
Abbreviations aCD3: Anti-CD3 monoclonal antibody ATG: Anti-thymocyte globulin E2: 17-oestradiol ER: Endoplasmic reticulum ESR: Oestrogen receptor FFPE: Formalin-fixed paraffin-embedded GLP-1: Glucagon-like peptide-1 GLP1-E2: Glucagon-like peptide-117-oestradiol conjugate GLP-1R: Glucagon-like peptide-1 receptor GLP-1RA: Glucagon-like peptide-1 receptor agonist ssGSEA: Single sample Gene Set Enrichment Analysis UPR: Unfolded protein response WBC: White blood cell References Ajmal N, Bogart MC, Khan P, Max-Harry IM, Healy AM, Nunemaker CS (2024) Identifying promising immunomodulators for type 1 diabetes (T1D) and islet transplantation
These include stomach cancer and kidney cancer
