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Hypertension 80(5):945955 Lee C, David T-W, Chang K-C, Lin T-T, Wu C-K, Lin L-Y (2024) Comparative analysis of mineralocorticoid receptor antagonists and renin-angiotensin system inhibitors/angiotensin receptor neprilysin inhibitor in heart failure with mildly reduced ejection fraction

Under normal circumstances, your body degrades excess histamine efficiently using two key enzymes: diamine oxidase (DAO) , which handles histamine from food in the gut, and histamine-N-methyltransferase (HNMT) , which processes histamine inside cells throughout the body

Its core mechanisms are closely related to disorders of cellular energy metabolism, accumulation of oxidative stress, and reduced capacity for DNA damage repair

For example, the reaction of cysteine with sugars in a Maillard reaction yields meat flavors

For people who dont break down histamine well, this can cause a reaction