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1 Nearly half of them present after intentionally taking a single large dose, while the rest present with unintentional toxicity while taking acetaminophen for pain relief on a long-term basis and ingesting more than the recommended dose

That's because it slows gastric emptying by reducing the speed with which food moves through the intestinal tract

Discovery and preclinical profile of Saxagliptin (BMS-477118): A highly potent, long-acting, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes

This side effect emerges because these medications intentionally slow gastric motility to reduce appetite, but the trade-off can include changes in how your gut bacteria process food

It helps ensure that therapeutic doses reach systemic circulation without the variability introduced by digestion