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NRF2 is known to participate in the regulation of several phase II enzymes, such as heme oxygenase-1 (HO-1) and UDP-glucuronosyltransferase (UGT)

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In summary, the reactivity of glutathione (GSH) is a crucial consideration for covalent drug development, leading to a growing focus on designing lower-reactivity warheads to minimize non-specific covalent binding and reduce the risk of adverse reactions

Consistent with expectations, bona fide p53 targets including HDM2 and CDKN1A were among the most highly up-regulated genes in Control cells, whereas genes known to be negatively regulated by p53, such as E2F2 , were strongly down-regulated (el-Deiry et al, 1993

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