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In fact, because of the then-dominating lock-and-key model of protein action and the associated central paradigm of structural biology stating that a unique 3D structure of a protein determines its function, all techniques for protein analysis were specifically designed for the analysis of the structural properties, conformational behavior, and thermodynamic stability of ordered proteins

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doi: 10.1056/NEJMoa2302392 143 GleasonPPUrickBYMarshallLZFriedlanderNQiuYLeslieRS