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Together, these findings suggest that cellular resistance to cuproptosis also depends on a hierarchically organized copper-buffering system, in which mtGSH provides rapid, dynamic metal buffering, whereas metallothioneins confer sustained high-affinity sequestration to prevent mitochondrial copper overload
Serum from RBD-NP-immunized nonhuman primates strongly cross-reacted with Pangolin-GD and RaTG13 RBDs but had weaker binding to distantly related RmYN02, SARS-CoV-1, WIV16, and ZXC21 RBDs [146]
Its recurrence, though not common, shows moderate to severe clinical features with possible recurrence
Their effects, while promising, are primarily observed in preclinical settings, and their clinical relevance in preserving ovarian function remains to be validated (Chen et al., 2022)