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The foregoing folic acid analogs and/or derivatives are conventionally termed "folates," reflecting their ability to bind with folate-receptors, and such ligands when conjugated with exogenous molecules are effective to enhance transmembrane transport, such as via folate-mediated endocytosis as described herein

When administered under physician supervision using pharmaceutical-grade compounds, peptide therapies have demonstrated favorable short-term safety profiles in clinical use

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