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This phenomenon is further complicated by reported no observed adverse effect levels (NOAELs) that vary by 23 orders of magnitude across studies, likely reflecting differences in metabolic processing, genetic susceptibility, and methodological approaches (9)

They are also the primary site where oxidative stress is generated as a byproduct of energy production

Laugel V, This-Bernd V, Cormier-Daire V, Speeg-Schatz C, de Saint-Martin A, et al

Do GLP-1 Analogs Have a Place in the Treatment of PCOS

Cell 181(4):914.e10-921.e10 Casalino L, Gaieb Z, Dommer AC, Harbison AM, Fogarty CA, Barros EP, Taylor BC, Fadda E, Amaro RE (2020) Shielding and beyond: the roles of glycans in SARS-CoV-2 spike protein