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Using this approach, several potential targets have been identified, including PRKACA, NCOA2, and PPARA, which play crucial roles in regulating neuroendocrine function, metabolism, and neuro-immunity [246]

Enzymatic Click Ligation: Selective Cysteine Modification in Polypeptides Enabled by Promiscuous Glutathione S-Transferase Enzymatic Click Ligation: Selective Cysteine Modification in Polypeptides Enabled by Promiscuous Glutathione S-Transferase Zhang C, Spokoyny AM, Zou Y, Simon MD, Pentelute BL., Angew Chem Int Ed Engl

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Supplementing with cysteine to increase glutathione is therefore of little use, except in a few severe and limited cases mainly used in clinical settings

Neuropsychiatric effects have been reported in post-marketing surveillance of GLP-1 receptor agonists, though the incidence and causal relationship remain unclear