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Patients often tell me they still think with their old appetite

Indeed, a recent perspective in Nature Sustainability warns that peptide drugs like GLP-1 agonists generate unsustainable volumes of toxic waste and non-degradable solid supports ( [20] )

patients should be counselled about symptoms of biliary colic Serious but rare adverse effects: Pancreatitis (discontinue immediately if suspected) Diabetic retinopathy complications (particularly in patients with pre-existing retinopathy and rapid glycaemic improvement) Acute kidney injury (usually in context of severe dehydration from vomiting/diarrhoea) Hypoglycaemia (particularly when used with insulin or sulfonylureas, which may require dose adjustment) Contraindications include: Known hypersensitivity to the medication Pregnancy and breastfeeding (for semaglutide, discontinue at least 2 months before planned conception

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It's used for minor, self-limited health issues where clinical decisions are simple and risk is minimal