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The most common side effects are gastrointestinal, including nausea (affecting 2040% initially), vomiting, diarrhoea, constipation, and abdominal discomfort

Clinical study FY25_DRA.36, Data on file

Although SF3B1 IDR lacks an RNA-binding domain, another study indicated that P-SF3B1 can associate with RNA, suggesting that in cells even a negatively charged phosphorylated form of the protein can contribute to the interaction with negatively charged RNA 29

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Early symptoms are often described as feeling like a severe flu: muscle aches, sweating, restlessness, anxiety, runny nose, and the beginning of cravings