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Conversely, there is no evidence for accumulation of valproyl-CoA in brain tissue, suggesting that the effects of VPA in the CNS are independent of the formation of this metabolite [80]

[11] [12] Often called Rboh, for respiratory burst oxidase homolog [13] Note that HO- production is also possible in the chloroplast lumen and in the mitochondrial intermembrane space

Multiscale modelling approach combining a kinetic model of glutathione metabolism with PBPK models of paracetamol and the potential glutathione-depletion biomarkers ophthalmic acid and 5-oxoproline in humans and rats

12: e0181387, doi: Baechle TR, Earle RW