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This condition disrupts cellular homeostasis and contributes to cellular injury and death, a process commonly referred to as lipotoxicity (Xu et al., 2022)
Mitochondrial dysfunction and changes in cellular energy metabolism play key roles in the pathophysiology of AKI
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Oxidative stress In a 2015 clinical trial involving 54 healthy adult participants, daily glutathione supplementation increased glutathione levels by an average of 3035% in plasma and red and white blood cells and reduced oxidative stress
The strategy of covalently conjugating metal-based anticancer agents to amphiphilic polymers, that could self-assemble into nanoparticles, could present a method for the tumor-selective anticancer therapy
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