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Moreover, integrating the recently developed 3D models of BBB into multiscale physiologically based cancer models offers better reflections of cellular dynamics than previous models, thus providing improved predictions of nanoparticle behaviour in the brain

One such advancement is transcervical fibroid ablation using radiofrequency energy, which allows targeted destruction of fibroid tissue through a small instrument inserted into the cervix

doi:10.1136/bmj.285.6337.264

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So loss in skeletal muscle (when it occurs) is more an indirect effect