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Biol Psychiatry 54 : 13301337

This inability may occur for a number of reasons

Anyone on sedating medications: combined effects are not well characterized

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These include: Over-the-counter pain medications like acetaminophen Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen Counterirritant gels or balms that contain menthol or camphor Lidocaine creams Topical forms of aspirin or NSAIDs Capsaicin cream, containing the active component in chili peppers Anticonvulsants and muscle relaxants Antidepressants Studies also show that nearly 45% of patients who received a diagnosis of neuropathy between 2014 and 2018 were also prescribed opioids