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423 Furthermore, the study emphasized that neurons in specific brain regions, such as the hindbrain and hypothalamus, co-express GLP-1R along with 1-adrenergic and -opioid receptors, suggesting a localized mechanism within the CNS that could coordinate peripheral anti-inflammatory responses

37 Future research is needed to investigate the role of GIP in inflammatory disorders and evaluate additional types of combination RAs in patients with chronic conditions associated with inflammation

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