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The relatively rapid FDA approval of sitagliptin for clinical use has been criticized [161], post-marketing reports reveal safety aspects that need further investigation [162], and it has even been suggested to restrict the use of gliptins to Phase IV clinical trials until cardiovascular safety is clearly established [163]

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One researcher, Beverly Tchang, suggested that using multiple pathways, as Retatrutide does, is the best way forward due to obesitys complexities

However, these are some of the converging themes despite the nuances posed by each specific disease

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