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Preclinical studies indicate that BI 1291583 can bind to human DPP1 in a covalent reversible manner, achieving selective DPP1 enzyme activity inhibition ( Regarding pharmacodynamic characteristics, BI 1291583 demonstrates superior inhibitory potency compared to other DPP1 inhibitors

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By maintaining redox homeostasis and modulating immune pathways, GSH improves resilience against infections and highlights its potential in host-directed immunotherapy strategies (8)

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